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Bioinformatics ERA-Chair, Head of the Bioinformatics Group

Bioinformatics ERA-Chair, Head of the Bioinformatics Group

George M. Spyrou, PhD

Bioinformatics ERA Chair,

Head of the Bioinformatics Group, The Cyprus Institute of Neurology and Genetics

ORCID 0000-0002-2470-3363

Research ID: O-7602-2018

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Synopsis

Dr. George M. Spyrou holds a BSc on Physics, an MSc on Medical Physics and an MSc on Bioinformatics as well. During his PhD he worked on algorithms and simulations focusing on breast cancer imaging. Early in 1990s Dr. Spyrou started thinking and working on the ways he could apply his knowledge in mathematics and physics on medicine and biology. In 1994 he joined the Medical Imaging Research Group of Prof. George Tzanakos at the Physics Department of University of Athens as Research Associate, working in the project of the small animal PET prototype design and construction. In 1998 he was selected by the Academician Prof. Panos Ligomenides to work at his Lab on a medical image analysis and decision support project concerning the early diagnosis of breast cancer. At the very beginning of the Biomedical Research Foundation of the Academy of Athens (BRFAA), the Foundation asked for an informatics-oriented scientist to be responsible for the design and development of the whole informatics infrastructure at BRFAA. Dr. Spyrou was then selected to take this responsibility being appointed as a Research Scientist of level B. Since 2001 and for over 10 years he worked on the strategic plan and implementation of IT development at BRFAA, acting as the Head of the Department of Informatics and New Technologies of BRFAA. Among his tasks was to design, organize and supervise from scratch the whole Information Technology infrastructure of the Institute. Namely, he had been involved in the design and supervision of network infrastructure, computational infrastructure, multimedia infrastructure, data services, web hosting services, administration databases, video/web conference services, e-learning, high performance computing infrastructure. In parallel, he was organizing his research group and was running his own research on bioinformatics and medical informatics. In 2007 Dr. Spyrou was promoted to Senior Research Scientist (Level A) at BRFAA after successful evaluation.  Since 2009 he is teaching a full semester course in the Postgraduate Program “Information Technologies in Medicine and Biology” at the University of Athens.  He is also a visiting instructor on Systems Bioinformatics and Network Analysis in other two postgraduate courses, namely the Master program on “Complex Systems and Networks” at the Aristotle University of Thessaloniki and the Master program on “Translational Research in Molecular Biology and Genetics” at the Democritus University of Thrace. Further to them, Dr. Spyrou has been instructor at the Greek National Centre for Public Administration and Local Government (EKDDA) for the period 2005-2014, with over 300 lecture hours. Through his teaching activities Dr. Spyrou has the opportunity of supervising/mentoring a number of MSc and PhD students. His work includes computational methods that act as bridges between molecular biology, systems biology and molecular medicine, exploiting computational intelligence and high performance computing for multi-omics network analysis, systems bioinformatics and in silico drug discovery. Up to now, he has served as Reviewer, Invited Speaker, Chairman and Scientific Advisory Board Member in topics related to Biomedical Informatics topics while he has authored over 160 scientific publications in peer reviewed journals and international conference proceedings. Dr. Spyrou is the Bioinformatics ERA Chair Holder and the Head of the Bioinformatics Group at the Cyprus Institute of Neurology and Genetics.

Memberships of Scientific Societies / Networks

Senior Member of the Institute of Electrical and Electronics Engineers (IEEE)
- Member of the IEEE Engineering in Medicine and Biology Society
- Member of the IEEE Computer Society
- Member of the European Virus Bioinformatics Center, Jena, Germany
- Representative of Cyprus in the Management Committee (MC Delegate) of the COST Action CA15120 entitled: “Open Multiscale Systems Medicine (OpenMultiMed)”.
- Member of the Steering Committee for the creation of the ELIXIR-Cyprus Node

 

 Teaching Activities / Coordinating Education 

 

2018- Assistant Coordinator for the CING’s Thematic Area “Personalized Medicine”
2018- Member of the Supervisory Board of the European Joint Doctorates Programme “STIMULATE” (H2020- Marie Sklodowska-Curie Innovative Training Networks)
2018  Chair and Organizer of the 4th OpenMultiMed Cost Training School in Systems Bioinformatics towards Network Medicine, May 29 – May 31, 2018 Cyprus
2017- Postgraduate Course Coordinator for the Bioinformatics Course (Full semester) at the Cyprus School of Molecular Medicine.
2017 Associate Faculty Position at the Cyprus School of Molecular Medicine.
2009-2015 Full Semester Course Teaching (“Simulation Methods in Medicine and Biology”) at the Postgraduate Program "Information Technologies in Medicine and Biology", organized by the Department of Informatics and Telecommunications of the National and Kapodistrian University of Athens.
2015- Visiting instructor on Systems Bioinformatics and Network Analysis in postgraduate Master’s program on “Complex Systems and Networks” at the Aristotle University of Thessaloniki, Greece.
2015- Visiting instructor on Systems Bioinformatics and Network Analysis in postgraduate the Master’s program on “Translational Research in Molecular Biology and Genetics” at the Democritus University of Thrace, Greece.
2009-2016 Member of the Steering Committee of the Postgraduate Program "Information Technologies in Medicine and Biology", organized by the Department of Informatics and Telecommunications of the National and Kapodistrian University of Athens.
2007-2010 Instructor at the Summer School “Methods in Micro – Nanotechnology and Nanobiotechnology” organized by the National Center for Scientific Research Demokritos. Topics: “Applied Bioinformatics in BioNanoTechnology” (2007, 2008) and “Structural Bioinformatics: Molecular Simulations and Visualization” (2009, 2010).
2005-2014 Instructor at the Greek National Centre for Public Administration and Local Government (EKDDA) with over 300 lecture hours on information technology topics.

Supervision of PostGraduate Students:
2016-         4 PhD Students (3 Co-supervisions and 1 Supervision - The Cyprus School of Molecular Medicine)
2008-2016 Supervised 3 completed PhDs from: School of Medicine, University of Patras and School of Electrical and Computer Engineering, National Technical University of Athens (1), Department of Informatics and Telecommunications, National and Kapodistrian University of Athens (2).
2002-2014 Co-supervised 4 completed PhDs from: School of Medicine, University of Patras (2), Health Informatics Laboratory, Faculty of Nursing, National and Kapodistrian University of Athens (1), School of Electrical and Computer Engineering, National Technical University of Athens (1).
2007-         Supervised 17 Master Students from: School of Medicine, University of Patras and School of Electrical and Computer Engineering, National Technical University of Athens (1), Department of Informatics and Telecommunications, University of Athens (14), The Cyprus School of Molecular Medicine (2).
                                

PUBLICATIONS IN PEER-REVIEWED JOURNALS AND VOLUMES

1. Emmanouil K. Ikonomakis, George M Spyrou, Michael N Vrahatis. Content driven clustering algorithm combining density and distance functions. Pattern Recognition, Volume 87, March 2019, Pages 190-202.
2. Andrea C. Kakouri, Christiana C. Christodoulou, Margarita Zachariou, Anastasis Oulas, George Minadakis, Christiana A. Demetriou, Christina Votsi, Eleni-Zamba Papanicolaou, Kyproula Christodoulou, George M. Spyrou. Revealing Clusters of Connected Pathways through Multisource Data Integration in Huntington’s disease and Spastic Ataxia. IEEE Journal of Biomedical and Health Informatics 2018 Aug 30.
3. G. Minadakis, M. Zachariou, A. Oulas, and G. M. Spyrou, "PathwayConnector: finding complementary pathways to enhance functional analysis," Bioinformatics, Aug 14 2018.
4. Margarita Zachariou, George Minadakis, Anastasis Oulas, Sotiroula Afxenti, George M. Spyrou. Integrating multi-source information on a single network to detect disease-related clusters of molecular mechanisms. J Proteomics. 2018 Mar 13. pii: S1874-3919(18)30104-0. doi: 10.1016/j.jprot.2018.03.009
5. Brili S, Oikonomou E, Antonopoulos AS, Pianou N, Georgakopoulos A, Koutagiar I, Kafouris P, Stroumpouli E, Dounis C, Metaxas M, Spyrou G, Anagnostopoulos CD, Tousoulis D. 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomographic Imaging Detects Aortic Wall Inflammation in Patients With Repaired Coarctation of Aorta. Circ Cardiovasc Imaging. 2018 Jan;11(1):e007002. doi: 10.1161/CIRCIMAGING.117.007002.
6. Nikolas Dovrolis, George Kolios, George Spyrou, Ioanna Maroulakou. Computational profiling of the gut-brain axis: Microflora dysbiosis insights to neurological disorders. Briefings in Bioinformatics 2017 Nov 27. doi: 10.1093/bib/bbx154.
7. Anastasis Oulas, George Minadakis, Margarita Zachariou, Kleitos Sokratous, Marilena M. Bourdakou, George M. Spyrou. Systems Bioinformatics: increasing precision of computational diagnostics and therapeutics through network-based approaches. Briefings in Bioinformatics 2017 Nov 27. doi: 10.1093/bib/bbx151.
8. Toutouzas K, Skoumas J, Koutagiar I, Benetos G, Pianou N, Georgakopoulos A, Galanakos S, Antonopoulos A, Drakopoulou M, Oikonomou EK, Kafouris P, Athanasiadis E, Metaxas M, Spyrou G, Pallantza Z, Galiatsatos N, Aggeli C, Antoniades C, Keramida G, Peters AM, Anagnostopoulos CD, Tousoulis D. Vascular inflammation and metabolic activity in hematopoietic organs and liver in familial combined hyperlipidemia and heterozygous familial hypercholesterolemia. J Clin Lipidol. 2017 Nov 2. pii: S1933-2874(17)30487-7. doi: 10.1016/j.jacl.2017.10.019.
9. Marilena M. Bourdakou and George M. Spyrou. Informed walks: whispering hints to gene hunters inside networks' jungle. BMC Syst Biol. 2017 Oct 11;11(1):97.
10. E. Karatzas, M. M. Bourdakou, G. Kolios & G. M. Spyrou. Drug repurposing in idiopathic pulmonary fibrosis filtered by a bioinformatics-derived composite score. Scientific Reports. 2017 Oct 3;7(1):12569.
11. Andreadis I, Chatzistergos S, Spyrou G, Nikita K. Fused man-machine classification schemes to enhance diagnosis of breast microcalcifications. Meas. Sci. Technol. (2017)
12. Protonotarios NE, Spyrou GM, Kastis GA. Automatic cumulative sums contour detection of FBP-reconstructed multi-object nuclear medicine images. Comput Biol Med. 2017 Apr 14;85:43-52.
13. Dovrolis Nikolas, Kolios George, Spyrou George, Maroulakou Ioanna. Laying in silico pipelines for drug repositioning: a paradigm in ensemble analysis for neurodegenerative diseases. Drug Discov Today. 2017 Mar 29. pii: S1359-6446(17)30135-6.
14. Toutouzas K, Koutagiar I, Benetos G, Aggeli C, Georgakopoulos A, Athanasiadis E, Pianou N, Trachanellis S, Patelis N, Agrogiannis G, Kafouris P, Filis K, Bessias N, Klonaris C, Spyrou G, Tsiamis E, Siores E, Patsouris E, Cokkinos D, Tousoulis D, Anagnostopoulos CD. Inflamed human carotid plaques evaluated by PET/CT exhibit increased temperature: insights from an in vivo study. Eur Heart J Cardiovasc Imaging. 2016 Dec 23. pii: jew219.
15. Tzanoukos G, Athanasiadis E, Gaitanis A, Georgakopoulos A, Chatziioannou A, Chatziioannou S, Spyrou G. SPNsim: A database of simulated solitary pulmonary nodule PET/CT images facilitating computer aided diagnosis. J Biomed Inform. 2016 Oct;63:357-365
16. Papadavid E, Braoudaki M, Bourdakou M, Lykoudi A, Nikolaou V, Tounta G, Ekonomidi A, Athanasiadis E, Spyrou G, Antoniou C, Kitsiou-Tzeli S, Rigopoulos D, Kolialexi A. Aberrant microRNA expression in tumor mycosis fungoides. Tumour Biol. 2016 Nov;37(11):14667-14675.
17. Kypreou KP, Stefanaki I, Antonopoulou K, Karagianni F, Ntritsos G, Zaras A, Nikolaou V, Kalfa I, Chasapi V, Polydorou D, Gogas H, Spyrou GM, Bertram L, Lill CM, Ioannidis JP, Antoniou C, Evangelou E, Stratigos AI. Prediction of Melanoma Risk in a Southern European Population Based on a Weighted Genetic Risk Score. J Invest Dermatol. 2016 Mar;136(3):690-5.
18. Athanasiadis E, Bourdakou M, Spyrou G. D-Map: Random walking on gene network inference maps towards differential avenue discovery. IEEE/ACM Trans Comput Biol Bioinform. 2016 Feb 26.
19. Bourdakou MM, Athanasiadis EI, Spyrou GM. Discovering gene re-ranking efficiency and conserved gene-gene relationships derived from gene co-expression network analysis on breast cancer data. Scientific Reports. 2016 Feb 19;6:20518.
20. Argiris Sakellariou and George Spyrou, “mAPKL: R/ Bioconductor package for detecting gene exemplars and revealing their characteristics”, BMC Bioinformatics 2015 Sep 15;16(1):291.
21. John C.Siavelis, Marilena M. Bourdakou, Emmanouil I. Athanasiadis, George M. Spyrou and Konstantina S. Nikita, “Bioinformatics methods in drug repurposing for Alzheimer’s disease”, Briefings in Bioinformatics, 2015 Jul 21. pii: bbv048.
22. Eleftheriou, S., Bourdakou, M., Athanasiadis, E., Spyrou, G. (2015). “GeneStoryTeller: A mobile app for quick and comprehensive information retrieval of human genes”, Database (Oxford). 2015 Jun 8;2015
23. Eleftherios Pilalis, Theodoros Koutsandreas, Ioannis Valavanis, Emmanouil Athanasiadis, George Spyrou, Aristotelis Chatziioannou (2015) “KENeV: A web-application for the automated reconstruction and visualization of the enriched metabolic and signaling super-pathways deriving from genomic experiments”, Computational and Structural Biotechnology Journal; 04/2015; 9. DOI:10.1016/j.csbj.2015.03.009
24. Athanasiadis, E., Bourdakou, M., Spyrou, G. (2015) “ZoomOut: Analyzing multiple networks as single nodes”. IEEE/ACM Transactions on Computational Biology and Bioinformatics 01/2015; DOI:10.1109/TCBB.2015.2424411
25. Antonopoulou,K., Stefanaki, I., Lill, C.M., Chatzinasiou, F., Kypreou, K., Karagianni, F., Athanasiadis, E., Spyrou, G.M., Ioannidis, J., Bertram, L., Evangelou, E., Stratigos, A. (2014) Updated field synopsis and systematic meta-analyses of genetic association studies in cutaneous melanoma: The MelGene database. Journal of Investigative Dermatology, 2015 Apr;135(4):1074-9.
26. Emmanouil I. Athanasiadis, Kyriaki Antonopoulou, Foteini Chatzinasiou, Christina M. Lill, Marilena M. Bourdakou, Argiris Sakellariou, Katerina Kypreou, Irene Stefanaki, Evangelos Evangelou, John P.A. Ioannidis, Lars Bertram, Alexander J. Stratigos and George M. Spyrou. A web-based database of genetic association studies in cutaneous melanoma enhanced with network-driven data exploration tools.”, Database (Oxford) (2014) Vol. 2014: article ID bau101; doi:10.1093/database/bau101.
27. Lionta E, Spyrou G, Vassilatis D, Cournia Z. Structure-Based Virtual Screening for Drug Discovery: Principles, Applications and Recent Advances. Curr Top Med Chem. 2014 Sep 29. [Epub ahead of print] PubMed PMID: 25262799.
28. Andreadis II, Spyrou GM, Nikita KS. A CADx Scheme for Mammography Empowered with Topological Information fromClustered Microcalcifications' Atlases. IEEE J Biomed Health Inform. 2014 Jul 25. [Epub ahead of print] PubMed PMID: 25073178.
29. Niarchou A, Alexandridou A, Athanasiadis E, Spyrou G. C-PAmP: large scale analysis and database construction containing high scoring computationally predicted antimicrobial peptides for all the available plant species. PLoS One. 2013 Nov 11;8(11):e79728.
30. Sakellaris T, Koutalonis M, Spyrou G, Pascoal A. A Monte Carlo study of the influence of focal spot size, intensity distribution, breast thickness and magnification on spatial resolution of an a-Se digital mammography system using the generalized MTF. Phys Med. 2014 May;30(3):286-95.
31. Paraskevopoulou MD, Vlachos IS, Athanasiadis E, Spyrou G. BiDaS: a web-based Monte Carlo BioData Simulator based on sequence/feature characteristics. Nucleic Acids Res. 2013 Jul;41(Web Server issue):W582-6.
32. Sakellariou A, Sanoudou D, Spyrou G, “Combining multiple hypothesis testing and affinity propagation clustering drives to accurate, robust and sample size independent classification on gene expression data, BMC Bioinformatics, 2012 Oct 17;13:270.
33. Athanasiadis E, Cournia Z, Spyrou G, “ChemBioServer: A web-based pipeline for filtering, clustering and visualization of chemical compounds used in drug discovery” Bioinformatics. 2012 Nov 15;28(22):3002-3
34. Foteini Chatzinasiou, Christina M. Lill, Katerina Kypreou, Irene Stefanaki, Vasiliki Nicolaou, George Spyrou, Evangelos Evangelou, Johannes T. Roehr, Elizabeth Kodela, Andreas Katsambas, Hensin Tsao, John P.A. Ioannidis, Lars Bertram, Alexander J. Stratigos, “Comprehensive Field Synopsis and Systematic Meta-analyses of Genetic Association Studies in Cutaneous Melanoma”, J Natl Cancer Inst. 2011 Aug 17;103(16):1227-35.
35. Alexandridou A, Dovrolis N, Tsangaris GT, Nikita K, Spyrou G. “PepServe: a web server for peptide analysis, clustering and visualization”, Nucleic Acids Res. 2011 Jul;39(Web Server issue):W381-4.
36. Anagnostopoulos AK, Tsiliki G, Spyrou G, Tsangaris GT, “Bioinformatics approaches in the discovery and understanding of reproduction-related biomarkers”, Expert Rev Proteomics. 2011 Apr;8(2):187-95.
37. I I Andreadis, G M Spyrou and K S Nikita, “A comparative study of image features for classification of breast microcalcifications”, Meas. Sci. Technol. 22 (2011)
38. A. G. Xanthopoulou, D. Anagnostopoulos, K. Vougas, A. Anagnostopoulos, A. Alexandridou, G. Spyrou, A.Siafaka-Kapadai, G.Th. Tsangaris, "A two-dimensional proteomic profile of Tetrahymena thermophila’s whole cell lysate", In Vivo. 2010 Jul-Aug;24(4):443-56.
39. T Sakellaris , G Spyrou , G Panayiotakis and G Tzanakos, “A Monte Carlo study of primary electron production inside photoconductors for digital mammography and indications of material suitability”, Journal of Instrumentation, 2010, doi:10.1088/1748-0221/5/08/P08004
40. Koutalonis M, Delis H, Pascoal A, Spyrou G, Costaridou L and Panayiotakis G, “Can electronic zoom replace magnification in mammography? A comparative Monte Carlo study”, Br J Radiol. 2010 Jul;83(991):569-77.
41. A.Sakellariou, D.Sanoudou, G. Spyrou, “Investigating the minimum required number of genes for the classification of neuromuscular disease microarray data”, IEEE Trans Inf Technol Biomed. 2011 May;15(3):349-55.
42. G. Giannakopoulou, G. Spyrou, A. Antaraki, I. Andreadis, D. Koulocheri, F. Zagouri, A. Nonni, G. Filippakis, K. Nikita, P. Ligomenides and G. Zografos, “Downgrading BIRADS 3 to BIRADS 2 category using a computer-aided microcalcification analysis and risk assessment system for early breast cancer”, Comput Biol Med. 2010 Oct 13.
43. A. Gaitanis, G. Kontaxakis, G. Spyrou, G. Panayiotakis, G. Tzanakos, “Studying the properties of the updating coefficients in the OSEM algorithm for iterative image reconstruction in PET”, Comput Methods Programs Biomed. 2010 Sep;99(3):219-29.
44. Ioannis K. Valavanis, George M. Spyrou and Konstantina Nikita, “A Similarity Network Approach for the Analysis and Comparison of Protein Sequence/Structure Sets”, J Biomed Inform. 2010 Apr;43(2):257-267
45. Ioannis K. Valavanis, George M. Spyrou and Konstantina Nikita, “A comparative study of multi-classification methods for protein fold recognition”, International Journal of Computational Intelligence in Bioinformatics and Systems Biology, Special Issue on “Classify the Classifiers: Investigating the Optimum Classification Technique per case in Bioinformatics”, Vol. 1,No3 2010
46. A. Gaitanis, G. Kontaxakis, G. Spyrou, G. Panayiotakis, G. Tzanakos, “PET image reconstruction: A stopping rule for the MLEM algorithm based on properties of the updating coefficients”, Comput Med Imaging Graph. 2010 Mar;34(2):131-41.
47. Konstantinos Vougas, Athina Samara, George Spyrou, George Th. Tsangaris, “Position Dominant Sequence Elements in Experimentally Verified Human Promoters and their Putative Relation to Cancer”, Cancer Genomics Proteomics. 2009 Nov-Dec;6(6):337-55
48. Frigas A, Spyrou G, Antaraki A, Patiraki E, Koufopoulos K, Mantas J, Ligomenides P. “Design of a 'smart' patient record system for mammography patients”. Stud Health Technol Inform, 2009, 150:130-4.
49. Anastasia Alexandridou, George Th. Tsangaris, Konstantinos Vougas, Konstantina Nikita and George Spyrou, “UniMaP: Finding Unique Mass and Peptide signatures in the Human Proteome”, Bioinformatics, 2009 Nov 15;25(22):3035-7
50. H Delis, V Vlachopoulou, G Spyrou, L Costaridou, G Tzanakos and G Panayiotakis, “Investigating the dependence of breast calcifications Signal to Noise Ratio on mammographic spectra: Monte Carlo simulation studies”, Journal of Instrumentation 4 P07007 doi: 10.1088/1748-0221/4/07/P07007
51. M. Koutalonis, H. Delis, G Spyrou, L. Costaridou, G. Tzanakos and G. Panayiotakis, “Monte Carlo simulation studies of spatial resolution in magnification mammography using the edge method”, Journal of Instrumentation 4 P05013 doi: 10.1088/1748-0221/4/05/P05013
52. T Sakellaris , G Spyrou , G Tzanakos and G Panayiotakis, “Photon and primary electron arithmetics in photoconductors for digital mammography: Monte Carlo simulation studies”, Journal of Instrumentation, doi: 10.1088/1748-0221/4/06/P06019
53. Antonios Frigas, George Spyrou, Panos Ligomenides, Marianna Diomidous, John Mantas, “Investigating the Classification Robustness of a Computer Aided Diagnosis System Using Mammographic Images”, Acta Informatica Medica, 2009, Vol. 17, No2: 64-6.
54. Anastasia Alexandridou, George Th. Tsangaris, Konstantinos Vougas, Konstantina Nikita and George Spyrou, “Peptide Finder: Mapping measured molecular masses to peptides and proteins”, Bioinformatics, 2008 Oct 1;24(19):2267-9
55. A.V. Vasilakos and G. Spyrou, “Computational Intelligence in Medicine and Biology: A Survey”, J. Comput. Theor. Nanosci. 5, 2365–2376 (2008)
56. Kolialexi A, Mavrou A, Spyrou G, Tsangaris GT., “Mass Spectrometry based proteomics in reproductive medicine”, Mass Spectrom Rev. 2008 Nov-Dec;27(6):624-34.
57. M Koutalonis, H Delis, G Spyrou, L Costaridou, G Tzanakos and G Panayiotakis, “Monte Carlo studies on the influence of focal spot size and intensity distribution on spatial resolution in magnification mammography”, Phys. Med. Biol., 2008 Mar 7;53(5):1369-84.
58. Sakellaris T, Spyrou G, Tzanakos G, Panayiotakis G., Energy, angular and spatial distributions of primary electrons inside photoconducting materials for digital mammography: Monte Carlo simulation studies. Phys Med Biol. 2007 Nov 7;52(21):6439-6460.
59. Delis H, Spyrou G, Tzanakos G, Costaridou L and Panayiotakis G: “Evaluating the Figure of Merit in mammography utilizing Monte Carlo simulation”, Nuclear Inst. and Methods in Physics Research, A, 580 (1), p.493-496, Sep 2007
60. Thireou T., Spyrou G., and Atlamazoglou V, “A Survey of the Availability of Primary Bioinformatics Web Resources", Genomics, Proteomics & Bioinformatics, 2007, 5(1): 70-76.
61. M Koutalonis, H Delis, G Spyrou, L Costaridou, G Tzanakos and G Panayiotakis, “Contrast to Noise Ratio in magnification mammography: a Monte Carlo study”, Phys. Med. Biol. 2007, 52, 3185-3199
62. Floros X, Spyrou G, Vougas K, Tsangaris G, Nikita K, “Study on Preprocessing and Classifying Mass Spectral Raw Data Concerning Human Normal and Disease Cases”, Lecture Notes in Computer Science, LNBI 4345, pp. 390–401, 2006.
63. G. Spyrou, S. Kapsimalakou A. Frigas K. Koufopoulos S. Vassilaros P. Ligomenides “"Hippocrates-mst": A prototype for Computer-Aided Microcalcification Analysis and Risk Assessment for Breast Cancer", Medical & Biological Engineering & Computing, 2006 Nov;44(11):1007-15
64. A Frigas, S Kapsimalakou, G Spyrou, K Koufopoulos, S Vassilaros, A Chatzimichael, J Mantas, P Ligomenides, “Evaluation of a Breast Cancer Computer Aided Diagnosis System”, Stud Health Technol Inform. 2006;124:631-6.
65. Delis H, Spyrou G, Costaridou L, Tzanakos G, Panayiotakis G. “Suitability of new anode materials in mammography: Dose and Subject Contrast considerations using Monte Carlo simulation” Medical Physics 2006; 33:4421-4435.
66. M Koutalonis, H Delis, G Spyrou, L Costaridou, G Tzanakos and G Panayiotakis “ Monte Carlo generated conversion factors for the estimation of average glandular dose in contact and magnification mammography”, Phys. Med. Biol. 51 No 21 (7 November 2006) 5539-5548
67. G. Tzanakos, M. Nikolaou, D. Drakoulakos, D. Karamitros, G. Kontaxakis, E. Logaras, G. Panayiotakis, S. Pavlopoulos, M. Skiadas, G. Spyrou, T. Thireou, D. Vamvakas “Design considerations and construction of a small animal PET prototype”, Nuclear Instruments and Methods in Physics Research Section, A, 569 (2), p.235-239, Dec 2006
68. Atlamazoglou V, Thireou T, Hamodrakas Y, Spyrou G. “MetaBasis: A Web-Based Database Containing Metadata on Software Tools and Databases in the Field of Bioinformatics”, Appl Bioinformatics 2006;5(3):187-92.
69. Sakellaris T, Spyrou G, Tzanakos G, Panayiotakis G. “Monte Carlo simulation of primary electron production inside an a-selenium detector for x-ray mammography: physics”, Phys Med Biol. 2005 Aug 21;50(16):3717-38.
70. Delis H, Spyrou G, Panayiotakis G, Tzanakos G. " DOSIS : A Monte Carlo Simulation Program for Dose Related Studies in Mammography", Eur J Radiol. 2005 Jun;54(3):371-6.
71. H Delis, G Spyrou, G Tzanakos and G Panayiotakis, “The influence of mammographic x-ray spectra on absorbed energy distribution in breast: Monte Carlo simulation studies”, Radiation Measurements, Volume 39, Issue 2, February 2005, Pages 149-155
72. G Spyrou, K Koufopoulos, S Vassilaros and P Ligomenides, “Computer Aided Image Analysis and Classification Schemes for the Early Diagnosis of Breast Cancer”, HERMIS International Journal of Computer mathematics and its Applications. Vol. 4. 2003, pp.175-181.
73. G Spyrou, M Nikolaou, M Koussaris, A Tsibanis, S Vassilaros and P Ligomenides, “A System for Computer Aided Early Diagnosis of Breast Cancer based on Microcalcifications Analysis”, European Systems Science Journal (Res-Systemica), Vol. 2, Special Issue, December 2002. Available online from http://www.afscet.asso.fr/resSystemica/
74. G Spyrou, G Tzanakos, G Nikiforides and G Panayiotakis, “A Monte Carlo simulation model of mammographic imaging with X-ray sources of finite dimensions”, Phys. Med. Biol. Vol. 47, Issue 21, March 2002, pp 917-933.
75. G Spyrou, G. Panayiotakis and G. Tzanakos, “MASTOS: Mammography Simulation Tool for design Optimization Studies”, Medical Informatics, Vol. 25, No 4, Oct.-Dec. 2000, pp 275-293.
76. G Spyrou, G Tzanakos, A Bakas and G Panayiotakis, “Monte Carlo Generated Mammograms: Development and Validation”, Phys. Med. Biol. Vol. 43, Issue 11, November 1998, pp 3341-57.

ANNOUNCEMENTS IN INTENATIONAL SCIENTIFIC CONFERENCES

1. Christodoulou CC, Demetrio CA, Sokratous K, Zamba-Papanicolaou E, Zachariou M, Oulas A, Minadakis G, Spyrou GM. Clusters of connected pathways through multisource data integration in huntingtons disease. The European Huntington's Disease Network Plenary Meeting, Austria, September 2018, DOI: 10.1136/jnnp-2018-EHDN.43 (J Neurol Neurosurg Psychiatry 2018;89:A16)
2. Christodoulou CC, Demetriou CA, Sokratous K, Spyrou GM, Zamba-Papanicolaou E. Neurodegenerative markers in hd: association with clinical charactersitcs, triplet expansion, phenoconversion and mediterranean diet adherence. The European Huntington's Disease Network Plenary Meeting, Austria, September 2018, DOI: 10.1136/jnnp-2018-EHDN.44 (J Neurol Neurosurg Psychiatry 2018;89:A16-A17.)
3. Anastasis Oulas, George Minadakis and George M. Spyrou, Classifying Variants of Unknown Significance by Combining Polygenic Risk Score and Network Analysis, The 6th International Conference of the Cyprus Society of Human Genetics, Nicosia Cyprus 24-25 Nov 2017.
4. Vassos Neocleous, Meropi Toumba, Charilaos Stylianou, Stella Nicolaou, Andreas Kyriakou, Meropi Dimitriadou, Kleitos Sokratous, George M. Spyrou, Pavlos Fanis, Athanasios Christoforidis, Leonidas A. Phylactou, Nicos Skordis, Novel Maternally Imprinted Defects In The MKRN3 Gene In Patients With Familial Central Precocious Puberty - 10th International Meeting of Pediatric Endocrinology, Washington USA, September 2017
5. Oulas A, Minadakis G and Spyrou GM. Network Based Approaches for Classifying Variants of Unknown Significance. Hellenic Bioinformatics Conference, 6-9 September 2017, FORTH, Heraklion, Greece.
6. Seitanidou C, Skrempou G, Psatha K, Oulas A, Drakos E, Spyrou GM and Aivaliotis M. Gene Co-expression Network Analysis on Mantle Cell Lymphoma Transcriptomics Data Sheds Light on Novel Diagnostic, Prognostic and Therapeutic Strategies. Hellenic Bioinformatics Conference, 6-9 September 2017, FORTH, Heraklion, Greece.
7. Styliani V. Brili; Constantinos Anagnostopoulos; Evangelos Oikonomou; Nikoletta Pianou; Emmanouil Athanasiadis; Alexandros Georgakopoulos; Pavlos Kafouris; George Spyrou; Iosif Cutajar; Petros Nihoyannopoulos; Dennis Cokkinos; Dimitris Tousoulis. The role of 18 f-fluorodeoxyglucose positron emission tomography in the investigation of regional aortic inflammation in patients with successfully repaired coarctation of the aorta. J Am Coll Cardiol. 2016;67(13_S):907-907.
8. Georgios Benetos; Konstantinos Toutouzas; Iosif Koutagiar; George Agrogiannis; Aleksandros Georgakopoulos; Nikoletta Pianou; Pavlos Kafouris; Sofoklis Trachanellis; Nikolaos Patelis; Nikolaos Bessias; Konstantinos Filis; Chris Klonaris; Efstratios Patsouris; Elias Siores; George Spyrou; Constantina Aggeli; Eleftherios Tsiamis; Dennis Cokkinos; Dimitris Tousoulis. Non-invasive assessment of atherosclerotic carotid plaques by 18f-fluorodeoxyglycose positron emission tomography/computed tomography (18f-fdg pet/ct) imaging and microwave radiometry (mwr): validation with histopathological findings. J Am Coll Cardiol. 2016; 67(13_S):1813-1813.
9. G Benetos , K Toutouzas , I Koutagiar , A Georgakopoulos , N Pianou , S Trachanellis , N Patelis , G Agrogiannis , N Bessias , K Filis , C Clonaris , G Spyrou , E Patsouris , CD Anagnostopoulos , D Tousoulis. Local inflammation of carotid atherosclerotic plaques evaluated by 18f-positron emission tomography is associated with increased temperature: validation with histopathological and immunohistochemistry. European Society of Cardiology (ESC) Congress, 27-31 August, 2016, Rome, Italy.
10. I Koutagiar , K Toutouzas , G Benetos , N Pianou , A Georgakopoulos , E Athanasiadis , S Galanakos, M Metaxas , G Spyrou , P Kafouris , D Cokkinos , D Tousoulis , CD Anagnostopoulos. Morphological and functional characteristics of the carotid plaques are not correlated: insights from positron emission tomography and microwave radiometry. European Society of Cardiology (ESC) Congress, 27-31 August, 2016, Rome, Italy.
11. S Brili , E Oikonomou , N Pianou , A Antonopoulos , E Athanasiadis , A Georgakopoulos , G Siasos , G Spyrou , P Kafouris , I Cutajar , C Anagnostopoulos , D Tousoulis. Regional inflammation of the aorta assessed by 18F-fluorodeoxyglucose positron emission tomography is associated with systemic inflammatory and echocardiographic indices in marfan syndrome. European Society of Cardiology (ESC) Congress, 27-31 August, 2016, Rome, Italy.
12. I Koutagiar , K Toutouzas , J Skoumas , G Benetos , P Kafouris , S Galanakos , M Metaxas , A Rigatou , G Spyrou , D Tousoulis , CD Anagnostopoulos. Higher arterial wall inflammation in familial combined hyperlipidemia (FCH) compared to familial hypercholesterolemia (hFH), independently of LDL levels. European Society of Cardiology (ESC) Congress, 27-31 August, 2016, Rome, Italy.
13. G Benetos , K Toutouzas , I Koutagiar , A Georgakopoulos , N Pianou , M Metaxas , G Agrogiannis , E Athanasiadis , G Spyrou , K Filis , E Siores (Bolton,GB), E Patsouris , D Cokkinos, D Tousoulis , CD Anagnostopoulos. Increased arterial inflammation assessed by positron emission tomography is associated with higher thermal heterogeneity and macrophage infiltration in carotid plaques. European Society of Cardiology (ESC) Congress, 27-31 August, 2016, Rome, Italy.
14. Georgios Benetos, Konstantinos Toutouzas, Iosif Koutagiar, Alexandros Georgakopoulos, George Agrogiannis, Nikolaos Bessias, Konstantinos Filis, Christos Klonaris, George Spyrou, Efstratios Patsouris, Constantinos Anagnostopoulos and Dimitris Tousoulis. Carotid Atherosclerotic Plaques With Increased Temperature Exhibit High Fdg-Pet Uptake: Validation With Histopathological Findings. Circulation. 2016;134:A15827
15. Georgios Benetos, Konstantinos Toutouzas, Iosif Koutagiar, Alexandros Georgakopoulos, George Agrogiannis, Emmanouil Athanasiadis, George Spyrou, Elias Siores, Pavlos Kafouris, Efstratios Patsouris, Dimitris Tousoulis and Constantinos Anagnostopoulos. Carotid Plaque Temperatures Assessed Noninvasively by Microwave Radiometry Are Associated With Fdg-pet Uptake Values and Macrophage Infiltration by Immunohistochemistry. Circulation. 2016;134:A15851
16. Iosif Koutagiar, Konstantinos Toutouzas, Georgios Benetos, Alexandros Georgakopoulos, Emmanouil Athanasiadis, Sofoklis Trachanellis, Nikolaos Patelis, Konstantinos Filis, Nikos Bessias, George Spyrou, Dimitrios Tousoulis and Constantinos Anagnostopoulos. Evaluation of Inflammation in Carotid Disease by New Imaging Modalities: Implications From 18-FDG PET/CT and Microwave Radiometry. Circulation. 2015;132:A14702
17. I Koutagiar , K Toutouzas , G Benetos , E Athanasiadis , K Filis , A Georgakopoulos , G Spyrou , DV Cokkinos , D Tousoulis , CD Anagnostopoulos. Carotid artery stenosis does not predict local inflammatory activation: Implications from new imaging modalities. European Society of Cardiology (ESC) Congress, August 29 - September 02, 2015; London, United Kingdom.
18. George M Spyrou, Simulations in Medicine and Biology: Insights and perspectives, Journal of Physics: Conference Series 574 (2015).
19. E. Kontopodis, V. Pierros, G. M. Spyrou, G. Th. Tsangaris, “Insights of the Human Proteome based on unique peptide analysis”, ΙΧ Annual Congress of the European Proteomics Association, ProteoInformatics Session, Milano, 23-28 June, 2015
20. Lykoudi, A., Kolialexi, A., Tounta, G., Papanikolaou, Th., Tsokaki, Th., Spyrou, G., Bourdakou, M., Athanasiadis, E., Mavrou, A., Papantoniou, N. (2015) Expression profile of miRNAs in human placentas from pregnancies Preeclampsia. 19th International Conference on prenatal diagnosis and therapy, 12 – 15 July 2015, Washington DC , USA.
21. E. Papadavid, G. Tounta, G. Spyrou, V. Nikolaou, M. Bourdakou, E. Athanasiadis, A. Lykoudi, A. Mavrou, C. Antoniou, A. Kolialexi, ”miRNA expression profile in tumor-stage mycosis fungoides”, EORTC Cutaneous Lymphoma Task Force meeting, Oct 24-26, 2014, Paris, France.
22. Ioannis Andreadis, George Spyrou, Konstantina Nikita, “Investigating the Performance of a CADx Scheme for Mammography in Specific BIRADS Categories”, 2014 IEEE International Conference on Imaging Systems & Techniques, Oct 14-17, Santorini, Greece.
23. Efthymios Maneas, Stratis Tzoumas, Vasilis Ntziachristos and George Spyrou, "Developing a Simulator for Multispectral Optoacoustic Tomography", The 13th IEEE International Conference on BioInformatics and BioEngineering (IEEE BIBE 2013), Chania, Greece, November 10-13, 2013
24. George Tzanoukos, Anastasios Gaitanis, Alexandros Georgakopoulos, Achilleas Chatziioannou, Sofia Chatziioannou, George Spyrou, "Modeling of Solitary Pulmonary Nodules in PET/CT images using Monte Carlo Methods", The 13th IEEE International Conference on BioInformatics and BioEngineering (IEEE BIBE 2013), Chania, Greece, November 10-13, 2013
25. Emmanouil Ikonomakis, George Spyrou, Panos Ligomenides, Michael Vrahatis, "Performance Evaluation of Clustering Algorithms on Microcalcifications as Mammography Findings", The 13th IEEE International Conference on BioInformatics and BioEngineering (IEEE BIBE 2013), Chania, Greece, November 10-13, 2013
26. Ioannis Andreadis, George Spyrou, Panos Ligomenides, Konstantina Nikita, "Generation of clustered microcalcifications’ atlases for benign and malignant cases", The 13th IEEE International Conference on BioInformatics and BioEngineering (IEEE BIBE 2013), Chania, Greece, November 10-13, 2013
27. Ioannis Andreadis, George Spyrou, Panos Ligomenides, Konstantina Nikita, "Variations on breast density and subtlety of the findings require different computational intelligence pipelines for the diagnosis of clustered microcalcifications", The 13th IEEE International Conference on BioInformatics and BioEngineering (IEEE BIBE 2013), Chania, Greece, November 10-13, 2013 (BEST STUDENT AWARD)
28. Alexandros C. Dimopoulos, John Lakoumentas, Argyro Antaraki, Antonios Frigas, Emmanouil K. Ikonomakis, Marinos Sampson, Anastasios Tagaris, Aikaterini Liakou, Emmanouil Athanasiadis, George Spyrou and Panos Ligomenides, “e-Prolipsis: A web based risk estimation platform to support and register breast cancer diagnosis in Greece”, 2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE), Larnaca, Cyprus, 11-13 November, 2012.
29. Paraskevi Gkeka, Emmanouil Athanasiadis, George Spyrou and Zoe Cournia, ” Enhancing the effectiveness of virtual screening by using the ChemBioServer: Application to the discovery of PI3Kα inhibitors”, 2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE), Larnaca, Cyprus, 11-13 November, 2012.
30. Katerina Karayianni, George Spyrou and Konstantina Nikita, Clustering Microarray Data using Fuzzy Clustering with Viewpoints”, 2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE), Larnaca, Cyprus, 11-13 November, 2012.
31. Sakellaris T, Koutalonis M, Spyrou G and Pascoal A, “A Monte Carlo study of the influence of breast thickness, breast composition and mean x-ray beam energy on the generalized image quality metrics of an a-Se digital mammography system”, Radiological Society of North America, 2012 Annual Meeting, November 2012, Chicago, USA.
32. Christos Pafilis, Anastasios Gaitanis, Chris Gatis, George Kontaxakis, George Spyrou, George Panayiotakis, George Tzanakos, “A methodology for the estimation of the optimal iteration in MLEM-based image reconstruction in PET”, 10th International Workshop on Biomedical Engineering, 5-7 October 2011, Kos Island, Greece
33. Sakellaris T., Pascoal A., Koutalonis M. And Spyrou G. “Developments of a Monte Carlo model to simulate digital mammography”, European Medical Physics and Engineering Conference 2011, September 2011, Dublin, Ireland.
34. Foteini Chatzinasiou, Christina M. Lill, George Spyrou, Katerina Kypreou, Irene Stefanaki, Vasiliki Nicolaou, Evangelos Evangelou, Johannes T. Roehr, Elizabeth Kodela, Andreas Katsambas, Hensin Tsao, John P.A. Ioannidis, Lars Bertram, Alexander J. Stratigos, “The MelGene database: A field synopsis of genetic association studies in cutaneous melanoma”, The 7th Congress of the European Association of Dermatologic Oncology, 20 – 23 June, 2011. Nantes, France
35. Fitousi N., Delis H., Spyrou G., Panayiotakis G., “A Simulation Tool for the in Silico Evaluation of Synchrotron Radiation in Breast Imaging”, 4th International Conference on Experiments/Process/ System Modeling/Simulation/Optimization (4th IC-EpsMsO) Athens, Greece, July 6th - July 9th, 2011
36. Konstantinos Eftaxias, Vissarion Fisikopoulos, George M. Spyrou, “In silico tomographic image generation using Monte Carlo and Computational Geometry”, The 10th IEEE International Conference on Information Technology and Applications in Biomedicine (ITAB 2010), November 2-5, 2010, Corfu, Greece
37. Anastasia Alexandridou, George Th. Tsangaris, Konstantina Nikita and George M. Spyrou, “Investigating the Uniqueness of Peptides in Human Signal and Bioactive Peptides”, The 10th IEEE International Conference on Information Technology and Applications in Biomedicine (ITAB 2010), November 2-5, 2010, Corfu, Greece
38. Andreadis, I. Nikita, K. Antaraki, A. Ligomenides, P. Spyrou, G., “Investigating the Image Features Landscape for the Classification of Breast Microcalcifications”, The 2010 IEEE International Conference on Imaging Systems and Techniques (IST), 1-2 July 2010, Thessaloniki, Greece.
39. Chatzinasiou F, Lill C, Kypraiou K, Stefanaki I, Nicolaou V, Spyrou G, Evangelou E, Roehr J, Kodela E, Katsambas A, Ioannidis J, Bertram L, Stratigos A, “Comprehensive Review and Field Synopsis of Genetic Associations in Cutaneous Melanoma”, The 6th Congress of the European Association of Dermatologic Oncology, June 16-19, 2010, Athens, Greece (Abstract in Melanoma Research: June 2010 - Volume 20 - Issue - pp e32-e33)
40. C. Pafilis, A. Gaitanis, C. Gatis, G. Kontaxakis, E. Logaras, S. Pavlopoulos, G. Panayiotakis, G. Spyrou, G. Tzanakos, D. Vamvakas, “Construction and initial studies of a two block small animal PET scanner”, Imaging 2010, International conference on imaging techniques in subatomic physics, astrophysics, medicine, biology and industry, 8-11 June 2010, Stockholm, Sweden
41. G. Giannakopoulou, D. Koulocheri, G. Spyrou, A. Antaraki, I. Andreadis, F. Zagouri, S. Kavvadias, P. Ligomenides, G. Zografos, “Computer-aided analysis and risk-assessment system of early breast cancer in daily clinical practice”, ECR 2010, European Congress of Radiology, 4-8 March 2010, Vienna, Austria
42. Koutalonis M, Pascoal A, Delis H, Costaridou L, Spyrou G and Panayiotakis G, “Can additional dose associated to magnification mammography be reduced through post-processing? Effect of contrast enhancement on Monte Carlo simulated images”, ECR 2010, European Congress of Radiology, 4-8 March 2010, Vienna, Austria
43. M Koutalonis, H Delis, G Spyrou and G Panayiotakis, “Optimization of geometric and electronic magnification in mammography: a Monte Carlo simulation study”, ECR 2009, European Congress of Radiology, March 6-10, Vienna, Austria.
44. Z. Antoniou, G. Giannakopoulou, I. Andreadis, K. Nikita, P. Ligomenides, and G. Spyrou, “A web-accessible mammographic image database dedicated to combined training and evaluation of radiologists and machines”, The 9th International Conference on Information Technology and Applications in Biomedicine (ITAB 2009), November 5-7, 2009, Larnaca, Cyprus
45. A. Sakellariou, D. Sanoudou and G. Spyrou, “Investigating the minimum required number of genes for optimum classification of myopathy microarray data”, The 9th International Conference on Information Technology and Applications in Biomedicine (ITAB 2009), November 5-7, 2009, Larnaca, Cyprus
46. A. Gaitanis, G. Kontaxakis, G. Spyrou, G. Panayiotakis, G. Tzanakos, “Log-likelihood-based rule for image quality monitoring in the MLEM-based image reconstruction for PET”, The IEEE Nuclear Science Symposium and Medical Imaging Conference, Orlando, Florida, USA, 25 - 31 October 2009
47. A Frigas, G Spyrou, A Antaraki, K Koufopoulos, E Patiraki, J Mantas, P Ligomenides, “Design of a 'smart' patient record system for mammography patients” Medical Informatics Europe (MIE) 2009, Sarajevo, Bosnia and Herzegovina, 30 August - 02 September 2009
48. Giannakopoulou G., Spyrou G., Koulocheri D., Antaraki A., Andreadis I., Zagouri F., Panopoulou E., Nonni A., Nikita K.S., Kavvadias S.X., Ligomenides P.A., Zografos G.C., “Preliminary experience of a risk assesment system “Hippocrates-mst” in atypical ductal hyperplasia and lobular neoplasia of the breast”, New European Surgical Academy (NESA) Congress and 5th Breast Symposium, Athens, Greece, May 28-30, 2009
49. Giannakopoulou G., Spyrou G., Koulocheri D., Antaraki A., Andreadis I., Zagouri F., Panopoulou E., Nonni A., Nikita K.S., Kavvadias S.X., Ligomenides P.A., Zografos G.C., “Unecessary breast biopsies reduction using a computer-aided diagnosis system (CAD) for microcalcifications”, New European Surgical Academy (NESA) Congress and 5th Breast Symposium, Athens, Greece, May 28-30, 2009
50. A. Gaitanis, G. Kontaxakis, G. Spyrou, G. Panayiotakis, G. Tzanakos, “Towards a Stopping Rule for the OSEM Algorithm for Iterative Image Reconstruction in PET”, The IEEE Nuclear Science and Medical Imaging Conference, Dresden, Germany, 19 - 25 October 2008
51. I. K. Valavanis, G. M. Spyrou, K. S. Nikita, “Protein Similarity Networks and Genetic Algorithm Driven Feature Selection for Fold Recognition”, 8th IEEE International Conference on BioInformatics and BioEngineering (BIBE 2008), 8-10 October 2008, Athens, Greece
52. V. Atlamazoglou, T. Thireou, A. Alexandridou, G. Spyrou, “A High Throughput Approach to Keep Alive a Web-Based Database System for Multiple Search Among Published Bioinformatics Tools and Databases”, 8th IEEE International Conference on BioInformatics and BioEngineering (BIBE 2008), 8-10 October 2008, Athens, Greece
53. Ioannis Andreadis, Konstantina Nikita, G. Giannakopoulou, D. Koulocheri, G. Zografos, A. Antaraki, P. Ligomenides, G. Spyrou, “Computer aided insights on obscure cases of breast cancer diagnosis”, the 2008 IEEE International Workshop on Imaging Systems and Techniques, 10-12 September 2008, Chania, Crete, Greece
54. Matthaios Koutalonis, Harry Delis, George Spyrou, Eleni Costaridou, George Panayiotakis, “Effect of detector blurring on spatial resolution in magnification mammography: A Monte Carlo study”, the 2008 IEEE International Workshop on Imaging Systems and Techniques, 10-12 September 2008, Chania, Crete, Greece
55. Harry Delis, George Spyrou, Eleni Costaridou, George Panayiotakis, “Mammographic Imaging Performance: Histogram Quantitative Metrics Using Monte Carlo Generated Images”, the 2008 IEEE International Workshop on Imaging Systems and Techniques, 10-12 September 2008, Chania, Crete, Greece
56. H Delis, V Vlachopoulou, G Spyrou, L Costaridou, G Tzanakos and G Panayiotakis, “Investigating the dependence of breast calcifications Signal to Noise Ratio on mammographic spectra: Monte Carlo simulation studies”, 4rth International Conference on Imaging Technologies in Biomedical Sciences: ITBS2007, Milos Island, Greece, 22-28 September 2007
57. M. Koutalonis, H. Delis, G Spyrou, L. Costaridou, G. Tzanakos and G. Panayiotakis, “Monte Carlo simulation studies of spatial resolution in magnification mammography using the edge method”, 4rth International Conference on Imaging Technologies in Biomedical Sciences: ITBS2007, Milos Island, Greece, 22-28 September 2007
58. T Sakellaris , G Spyrou , G Tzanakos and G Panayiotakis, “Photon and primary electron arithmetics in photoconductors for digital mammography: Monte Carlo simulation studies”, 4rth International Conference on Imaging Technologies in Biomedical Sciences: ITBS2007, Milos Island, Greece, 22-28 September 2007
59. Ioannis Valavanis, George Spyrou, Konstantina Nikita, "Investigating the structure of protein similarity networks both on sequence and structure level", 8th Hellenic European Conference on Computer Mathematics and its Applications – HERCMA 2007, 20-22 September 2007, Athens.
60. I. Andreadis, G. Spyrou, A. Antaraki, G.Zografos, D. Kouloheri, G. Giannakopoulou, K. S. Nikita & P. A. Ligomenides, " Combining SVM and Rule Based Classifiers for optimal classification in breast cancer diagnosis", 8th Hellenic European Conference on Computer Mathematics and its Applications – HERCMA 2007, 20-22 September 2007, Athens.
61. A Frigas, G Spyrou, G Zografos, D Koulocheri, J Mantas, P Ligomenides, “Clinical trial of a CAD system for microcalcification detection and classification”, 12th World Congress on Health (Medical) Informatics, MEDinfo2007, Brisbane Convention Centre, 20–24 August, 2007.
62. A. Gaitanis, G. Kontaxakis, G. Panayiotakis, G. Spyrou & G. Tzanakos, “The role of the updating coefficient of the ML-EM algorithm in PET image reconstruction”, Annual Congress of European Association of Nuclear Medicine (EANM) 2006, 30 September – 4 October 2006, Athens - Eur. J. Nucl. Med Mol.Imag., 33 (Suppl. 2):314, 2006.
63. M. Koutalonis, H. Delis, G. Spyrou, L. Costaridou1, G. Tzanakos and G. Panayiotakis, “Monte Carlo assessment of average glandular dose and percentage depth dose in magnification mammography”, 10th International Symposium on Radiation Physics (ISRP-10), 17-22 September, 2006, Coimbra, Portugal.
64. H. Delis, G. Spyrou, L. Costaridou, G. Tzanakos and G. Panayiotakis, “Evaluating the figure of merit in mammography utilizing Monte Carlo simulation”, 10th International Symposium on Radiation Physics (ISRP-10), 17-22 September, 2006, Coimbra, Portugal.
65. A Frigas, S Kapsimalakou, G Spyrou, K Koufopoulos, S Vassilaros, A Chatzimichael, J Mantas, P Ligomenides, “Evaluation of a Breast Cancer Computer Aided Diagnosis System”, The 20th International Congress of the European Federation for Medical Informatics - MIE2006, 27-30 August 2006, Maastricht, the Netherlands
66. Frigas Α, Spyrou G, Zografos G, Koulocheri D, Mantas J, Ligomenides P, “Using a computer-aided diagnosis prototype for breast cancer in daily clinical practice”, The 4th International Conference on Information Communication Technologies in Health, ICICTH Samos 2006, Greece, July 13-15, 2006
67. M. Koutalonis, H. Delis, G. Spyrou, L. Costaridou, G. Tzanakos and G. Panayiotakis, “Dosimetry in contact and magnification mammography, using Monte Carlo simulation”, The International Association of Science and Technology for Development (IASTED) Conference on Applied Simulation and Modeling, Rhodes, Greece, June 26-28, 2006
68. Georgios Archontis, George Spyrou, Vassiliki Ikonomidou and Stavros Hamodrakas, “Simulations of amyloid fiber formation in peptide analogues of silkmoth chorion proteins”, Workshop on Protein Aggregation, CECAM Centre Europeen de Calcul Atomique -Moleculaire, May 2006, Lyon, France
69. A. Gaitanis, G. Kontaxakis, G. Panayiotakis, G. Spyrou, G. Tzanakos, “PET Image Reconstruction: A Stopping Criterion Based on the Updating Coefficients of the ML-EM Algorithm”, The 1st European Conference on Molecular Imaging Technology, 9-12 May 2006, Marseille, France
70. D. Drakoulakos, D. Karamitros, G. Kontaxakis, E. Logaras, M. Nikolaou, G. Panayotakis, S. Pavlopoulos, M. Skiadas, G. Spyrou, T. Thireou, D. Vamvakas and G. Tzanakos, “Design Considerations and Construction of a Small Animal PET Prototype”, 3rd International Conference on Imaging Technologies in Biomedical Sciences: ITBS2005, Milos Island, Greece, 25-28 September 2005
71. Frigas Α, Spyrou G, Koufopoulos K, Vassilaros S, Mantas J , Ligomenides P, “Using modules of a computer aided diagnosis system in an advanced training scheme for radiologists”, the 7th Hellenic European Conference on Computer Mathematics and its Applications – HERCMA 2005, September 22-24, 2005.
72. Dovrolis N., Kokkoris E., Printezi F., Schalekis N. and Spyrou G., “A cell-like approach to grid computing”, the 7th Hellenic European Conference on Computer Mathematics and its Applications – HERCMA 2005, September 22-24, 2005.
73. H. Delis, G. Spyrou, G. Tzanakos, L. Costaridou and G. Panayiotakis. "Dose and Image Optimization in Mammography: Monte Carlo Simulation Studies", Biomedizinische Technik (Biomedical engineering), Vol. 50 (s2), 1336-1337, Proceedings of the 14th International Conference of Medical Physics, September 2005, Nuremberg, Germany.
74. H. Delis, G. Spyrou, V. Vlachopoulou, L. Costaridou, G. Tzanakos and G. Panayiotakis. "Pathological findings detectability dependence on mammographic spectra using Monte Carlo simulation", 1st International Conference on Experiments/ Process / System Modelling/ Simulation / Optimization, June 2005, Athens, Greece.
75. H. Delis, G. Spyrou, G. Tzanakos and G. Panayiotakis. “Generation of theoretical mammographic spectra for Monte Carlo based simulation studies”, 1st International Conference on Experiments/ Process / System Modelling/ Simulation / Optimization, June 2005, Athens, Greece.
76. Frigas A, Spyrou G, Mantas J, Ligomenides P, “Design of a training scheme for radiologists based on a computer aided diagnosis system”, European Federation for Medical Informatics (EFMI) Special Topic Conference, March 2005, Athens, Greece.
77. H Delis, G Spyrou, G Tzanakos and G Panayiotakis, “Dose And Image Characteristics Of New Mammographic Anode Materials. Monte Carlo Simulation Studies”, European Congress of Radiology, Vienna, Austria, 2005.
78. M. Nikolaou , D. Drakoulakos, D. Karamitros, G. Kontaxakis, E. Logaras, G. Panayotakis,S. Pavlopoulos, M. Skiadas, G. Spyrou, T. Thireou, G. Tzanakos, D. Vamvakas, “Tests and Measurements for Characteristics Optimization of Photomultiplier Tubes used in a Positron Emission Tomography System”. The IEEE Nuclear Science and Medical Imaging Conference, Rome Italy, October 16-22 2004
79. S. Pavlopoulos, D. Drakoulakos, D. Karamitros, G. Kontaxakis, E. Logaras, M. Nikolaou, G. Panayotakis, M. Skiadas, G. Spyrou, T. Thireou, G. Tzanakos, D. Vamvakas, “Design Considerations and Initial Evaluation of a Small Animal PET Prototype”. The IEEE Nuclear Science and Medical Imaging Conference, Rome Italy, October 16-22 2004
80. H Delis, G Spyrou, G Tzanakos and G Panayiotakis: “ Absorbed Energy Distribution in Breast during Mammography: Monte Carlo Simulation Studies”, the 1st International Conference “From Scientific Computing to Computational Engineering”, September 2004, Athens, Greece
81. T. Sakellaris, G. Spyrou, G. Tzanakos and G. Panayiotakis: “Distributions Of X-Ray Generated Primary Electrons In a-Se: Monte Carlo Simulation Studies”, the 1st International Conference "From Scientific Computing to Computational Engineering", September 2004, Athens, Greece
82. T Sakellaris, G. Spyrou, G. Tzanakos and G. Panayiotakis. “Digital Mammography using a-Se: Monte Carlo Generated Energy and Spatial Distributions of Primary Electrons”, the X Mediterranean Conference on Medical and Biological Engineering and Computing, Aug 2004, Ischia, Italy.
83. H. Delis, G. Spyrou, T. Sakellaris, G. Tzanakos and G. Panayiotakis. “Dosimetric Charactreristics Of New Anode Materials In Mammography: Monte Carlo Simulation Studies”, the X Mediterranean Conference on Medical and Biological Engineering and Computing, August 2004, Ischia, Italy.
84. G. Spyrou, K. Koufopoulos, S. Vassilaros and P.Ligomenides, “Computer Aided Image Analysis and Classification Schemes for the Early Diagnosis of Breast Cancer”, 6th Hellenic European Conference on Computer Mathematics and its Applications, HERCMA 2003, September 25-27, 2003
85. G. Tzanakos, G. Kontaxakis, M. Nikolaou, G. Panayotakis, S. Pavlopoulos, M. Skiadas, G. Spyrou and T. Thireou, “Design and Construction of a Small Animal PET Prototype”, IEEE Nuclear Science and Medical Imaging Conference, Norfolk, Virginia, USA, November 2002
86. G. M. Spyrou, M. G. Nikolaou, K. N. Koufopoulos and P. A. Ligomenides, “A computer based model to assist in improving early diagnosis of breast cancer”, 7th World Congress on Advances in Oncology and 5th International Symposium on Molecular Medicine, October 10-12, 2002, Creta Maris Hotel, Hersonissos, Crete, Greece
87. G. Tzanakos, D Georgakakis, G Kontaxakis, M Skiadas, N Apostolou, S Pavlopoulos, T Thireou, M Nikolaou, G Panayiotakis, G Spyrou, “Design of a PET Tomograph for Small Animal Research”, IEEE Nuclear Science Symposium and Medical Imaging Conference, San Diego, California, 2001
88. H. Delis, G. Spyrou, G. Tzanakos and G. Panayiotakis, “A dosimetric survey of different mammographic spectra using Monte Carlo simulation”, Conference Proceedings pp 799 – 802, IX Mediterranean Conference on Medical and Biological Engineering and Computing, Medicon 2001, June 12-15, 2001, Pula, Croatia
89. M. E. Nikolaou, G. Spyrou, G. Panayiotakis and G. Tzanakos, “Design Studies of Collimated Gamma Ray Sources”, CD-ROM Conference Proceedings, 2000 IEEE Nuclear Science Symposium and Medical Imaging Conference, Oct. 15-20, 2000, Lyon, France
90. G. Tzanakos, N. Apostolou, X. Benetou, G. Karmaniolas, G. Kontaxakis, M. Nikolaou, G. Panayiotakis, S. Pavlopoulos, M. Skiadas, G. Spyrou, T. Thireou, CD-ROM Conference Proceedings, “Development of a Small Animal PET Prototype”, 2000 IEEE Nuclear Science Symposium and Medical Imaging Conference, Oct. 15-20, 2000, Lyon, France
91. G. Tzanakos, G. Spyrou, G. Panayiotakis, “The Influence of Focal Spot Characteristics on Mammographic Resolution: Monte Carlo Simulation Studies”, Physica Medica – Vol. XV, N.3, July-September 1999, p.198, Proceedings of the VI International Conference on Medical Physics, Patras Medical Physics ’99, 1-4 Sept., 1999, Greece