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Publications in Scientific Journals and Book Chapters

Posted 01 March 2018 by In Publications


Selecting variants of unknown significance through network-based gene-association significantly improves risk prediction for disease-control cohorts
Anastasis Oulas, George Minadakis, Margarita Zachariou, and George Spyrou 
Scientific Reports (Nature). 2019 Feb 1




An Application of Computational Drug Repurposing Based on Transcriptomic Signatures.
Karatzas E, Kolios G, Spyrou GM.
Methods Mol Biol. 2019;1903:149-177.

Inhibition of breast cancer cell invasion by Ras suppressor-1 (RSU-1) silencing is reversed by Growth Differentiation Factor-15 (GDF-15)
Vasiliki Gkretsi, Maria Louca, Andreas Stylianou, George Minadakis, George Spyrou, Triantafyllos Stylianopoulos.
Int J Mol Sci. 2019 Jan 4;20(1)






Adjustment of vascular 2-deoxy-2-[18F]fluoro-D-glucose uptake values over time through a modeling approach
Pavlos Kafouris, Iosif Koutagiar, Alexandros Georgakopoulos, Nikoletta Pianou, Marinos Metaxas, George Spyrou, Constantinos Anagnostopoulos.  
The International Journal of Cardiovascular Imaging, December 2018





Content driven clustering algorithm combining density and distance functions
Emmanouil K. Ikonomakis, George M Spyrou, Michael N Vrahatis
Pattern Recognition. Volume 87, March 2019, Pages 190-202

Link to the paper




PathwayConnector: finding complementary pathways to enhance functional analysis
George Minadakis, Margarita Zachariou, Anastasis Oulas, and George M. Spyrou
Bioinformatics . 2018 Aug 14. doi:10.1093/bioinformatics/bty693.

Link to the paper



Revealing Clusters of Connected Pathways through Multisource Data Integration in Huntington’s disease and Spastic Ataxia
Andrea C. Kakouri, Christiana C. Christodoulou, Margarita Zachariou, Anastasis Oulas, George Minadakis, Christiana A. Demetriou, Christina Votsi, Eleni-Zamba Papanicolaou, Kyproula Christodoulou, George M. Spyrou
IEEE Journal of Biomedical and Health Informatics . 2018 Aug

Link to the paper



Integrating multi-source information on a single network to detect disease-related clusters of molecular mechanisms.
 M. ZachariouG. MinadakisA. Oulas, S. Afxenti,  G. M. Spyrou
 J Proteomics. 2018 Mar 13. pii: S1874-3919(18)30104-0. doi: 10.1016/j.jprot.2018.03.009.

Link to the paper




Circulation: Cardiovascular Imaging, volume 11 issue 1 cover

18F-Fluorodeoxyglucose Positron Emission tomography/Computed Tomographic Imaging Detects Aortic Wall Inflammation in Patients With Repaired Coarctation of Aorta.
Brili S, Oikonomou E, antonopoulos AS. Pianou N, Georgakopoulos A, Koutagiar I, Kafouris P, Stroumpouli E, Dounis C, Metaxas M,  Spyrou G, Anagnostopoulos CD, and Tousoulis D.
Circ Cardiovasc Imaging. 2018 Jan 11(1):e007002. doi: 10.1161/CIRCIMAGING.117.007002.

Link to the paper





 Systems Bioinformatics: increasing precision of computational diagnostics and therapeutics through network-based approaches.
 A. Oulas, G. Minadakis, M. Zachariou, K. Sokratous, M. M. Bourdakou, G. M. Spyrou.  
 Briefings in Bioinformatics. 2017 Nov 27. doi: 10.1093/bib/bbx151. 

 Link to the paper




 Computational profiling of the gut-brain axis: microflora dysbiosis insights to neurological disorders.

 Dovrolis N, Kolios G, Spyrou GM, Maroulakou I.  
 Briefings in Bioinformatics. 2017 Nov 27. doi: 10.1093/bib/bbx154.

 Link to the paper




 Informed walks: whispering hints to gene hunters inside networks' jungle. 
 Marilena M. Bourdakou and George M. Spyrou.
 BMC Systems Biology. 2017 Oct 11;11(1):97. doi: 10.1186/s12918-017-0473-6.

 Link to the paper




 Drug repurposing in idiopathic pulmonary fibrosis filtered by a bioinformatics-derived composite score.
 E. Karatzas, M. M. Bourdakou, G. Kolios & G. M. Spyrou
 Scientific Reports (Nature). 2017 Oct 3;7(1):12569. doi: 10.1038/s41598-017-12849-8.
  Link to the paper




 Laying in silico pipelines for drug repositioning: a paradigm in ensemble analysis for neurodegenerative diseases.
 Dovrolis Nikolas, Kolios George, Spyrou George, Maroulakou Ioanna.
 Drug Discov Today. 2017 Mar 29. pii: S1359-6446(17)30135-6.
Link to the paper




 Sediment microbial taxonomic and functional diversity in a natural salinity gradient challenge Remane’s "species minimum" concept.
 Christina Pavloudi, Jon B Kristoffersen, Anastasis Oulas, Marleen De Troch, Christos Arvanitidis.  
 PeerJ. 2017 Oct 13;5:e3687. doi: 10.7717/peerj.3687. eCollection 2017.
 Link to the paper



 Pharmacological Stimulation of Phagocytosis Enhances Amyloid Plaque Clearance; Evidence from a Transgenic Mouse Model of ATTR Neuropathy.
 Eleni Fella, Kleitos Sokratous, Revekka Papacharalambous, Kyriakos Kyriakou, Joy Phillips, Sam Sanderson, Elena Panayiotou, Theodoros Kyriakides.   
 Front. Mol. Neurosci. 2017 May 10;10:138. doi: 10.3389/fnmol.2017.00138. eCollection 2017.
 Link to the paper



 Fused man-machine classification schemes to enhance diagnosis of breast microcalcifications.
 Andreadis I, Chatzistergos S, Spyrou G, Nikita K.
 Meas. Sci. Technol. (2017) 28 114003
 Link to the paper





 Automatic cumulative sums contour detection of FBP-reconstructed multi-object nuclear medicine images.
 Protonotarios NE, Spyrou GM, Kastis GA.
 Comput Biol Med. 2017 Jun 1;85:43-52. doi: 10.1016/j.compbiomed.2017.04.010. Epub 2017 Apr 14.

 Link to the paper





 Seqenv: linking sequences to environments through text mining.
 L Sinclair, U Z Ijaz, L J Jensen, M Coolen, C Gubry-Rangin, S Berger, A Chroňáková, A Oulas, C Pavloudi, J Schnetzer, A Weimann, A Z Ijaz, A Eiler, C Quince, E Pafilis.  
 PeerJ. 2016 Dec 20;4:e2690. doi: 10.7717/peerj.2690. eCollection 2016.
 Link to the paper